Osteoporosis- Arthritis

• Fast result
• No side effect
• Effectiveness

• Hypercalcaemia due to malignancy, hypercalcaemia of malignancy.
• The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone.
• Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins.
• This activity inhibits osteoclast activity and reduces bone resorption and turnover.

• Arachitol This medication is a synthetic vitamin D analog, prescribed for hypocalcemia in patients undergoing chronic renal dialysis.

• Risofos is used to treat and prevent osteoporosis by slowing calcium loss from the bones, reducing the action of the osteoclasts
• How much you take and how often will depend on the strength of the Risofos and your condition. Take strictly as directed by your physician, with a glass of water at least 30 minutes before your first meal or drink of the day. Take Risofos either standing or sitting upright with a full glass of plain water. Do not lie down for at least 30 minutes after taking this medication.
• Do not alter your dose or suddenly stop taking Risofos without consulting your physician, even if you are feeling better. If you do, your symptoms may worsen and increase the risk of unwanted side effects. If you forget to take a dose, take it as soon as you remember if you have not already eaten. If you have eaten, skip the missed one and continue with your regular schedule. Never take a double dose to make up for the one you missed.

• Arachitol This medication is a synthetic vitamin D analog, prescribed for hypocalcemia in patients undergoing chronic renal dialysis.

Aclasta belongs to the family of medications known as bisphosphonates. It is used to treat Paget's disease of the bone. It is also used to treat osteoporosis in men, to treat and prevent osteoporosis in postmenopausal women, and to treat and prevent osteoporosis caused by steroid medications.

Below are some of the details of Ibandronate(generic)

Ibandronate, a bisphosphate group of drug, is prescribed for the therapeutic management and prevention of osteoporosis in postmenopausal women. Ibandronate interferes with bone metabolism including bone formation and breakdown. Ibandronate delays bone loss, increase bone mass and prevent pathological bone fractures.

Risofos is used to treat and prevent osteoporosis by slowing calcium loss from the bones, reducing the action of the osteoclasts

How much you take and how often will depend on the strength of the Risofos and your condition. Take strictly as directed by your physician, with a glass of water at least 30 minutes before your first meal or drink of the day. Take Risofos either standing or sitting upright with a full glass of plain water. Do not lie down for at least 30 minutes after taking this medication.

Do not alter your dose or suddenly stop taking Risofos without consulting your physician, even if you are feeling better. If you do, your symptoms may worsen and increase the risk of unwanted side effects. If you forget to take a dose, take it as soon as you remember if you have not already eaten. If you have eaten, skip the missed one and continue with your regular schedule. Never take a double dose to make up for the one you missed.

Risofos is used to treat and prevent osteoporosis by slowing calcium loss from the bones, reducing the action of the osteoclasts

How much you take and how often will depend on the strength of the Risofos and your condition. Take strictly as directed by your physician, with a glass of water at least 30 minutes before your first meal or drink of the day. Take Risofos either standing or sitting upright with a full glass of plain water. Do not lie down for at least 30 minutes after taking this medication.

Do not alter your dose or suddenly stop taking Risofos without consulting your physician, even if you are feeling better. If you do, your symptoms may worsen and increase the risk of unwanted side effects. If you forget to take a dose, take it as soon as you remember if you have not already eaten. If you have eaten, skip the missed one and continue with your regular schedule. Never take a double dose to make up for the one you missed.

Rispfos Kit contains Cholecalciferol Calcium Risedronate

It is a biphosphonate

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Prevention of osteoporosis, Paget's disease

Upset stomach, flatulence, bloating, constipation, diarrhoea, heartburn, bone or joint pain, leg cramps, acid reflux, GI irritation, dizziness, nervousness, sinusitis, dry eyes, changes in vision, ringing in the ears, head ache, back pain.

Calcium and vitamin D supplements should be taken

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35mg daily once a day should be taken 30 minutes or more before first food of the day with 200ml of plain water 9 do not take with mineral water, orange juice, dairy product). Do not lie down or atleast 30 minutes after taking residronate.

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The action of ibandronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover.

Used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis.